Recent Publications
2026
Sheida Mirloo, Lyna Kamintsky, Shayna Cort, Jamil Muradov, Saara Mansoor, Laith Alhadeed, Alaa Abu Ahmad, Basim Shafiq, Amirhossein Talebanpour, Rotem Saar-Ashkenazy, Yonatan Serlin, Alon Friedman (2026) Fluids and Barriers of the CNS
Amirhossein Talebanpour, Sheida Mirloo, Alireza Aleali, Lyna Kamintsky, Yonatan Serlin, Nir Cafri, Ilan Goldberg, Chris Bowen, Gal Ben-Arie, Theodor Rüber, Felix Benninger, Ben Whatley, Alon Friedman (2026) NeuroImage: Clinical
Sheida Mirloo, Sheizaf Shpilberg, Noam Druker, Rotem Saar-Ashkenazy, Ofer Prager, Shai Baruch Neustaedter, Gal Ben-Arie, Ilan Shelef, Lyna Kamintsky, Yonatan Serlin, Danielle K. Sandsmark, Alon Friedman, and Hadar Shalev (2026) Brain Communications
Kola Vasilis, Prabin Basnet, Viktor Horst, Sebastian Major, Coline Lemale, Nils Hecht, Maren Winkle Karl Schoknecht, Svetlana Lublinsky, Stefan Wolf, Peter Vajkoczy, Michael Scheel, Jed A. Hartings, Alon Friedman , Johannes Woitzik, Peter Martus, Jens Dreier (2026) Journal of Cerebral Blood Flow and Metabolism https://doi.org/10.1177/0271678X261463954
Boyer-Aymé, Florent J. M.; Imtiaz, Hamza; Prager, Ofer; Swissa, Evyatar; Ahmad, Alaa Abu; Serlin, Yonatan; Aboghazleh, Refat; Goldberg, Ilan; Caller, Maayan Ben nun; Tamir, Idit; Shor, Oded; Whatley, Benjamin; Benninger, Felix; Alon Friedman (2026) Epilepsia doi.org/10.1002/epi.70333
de Curtis, Marco; Battaglia, Giulia; Aguado-Carrillo, Gustavo; Aronica, Eleonora; Asukile, Melody; Balestrini, Simona; Barba, Carmen; Baumgartner, Tobias; Becker, Albert; Bisulli, Francesca; Braga, Patricia; Carcak Yilmaz, Nihan; Cavalheiro, Esper; Delanty, Norman; Ferri, Lorenzo; Friedman, Alon; Friedman, Daniel; Galovic, Marian; Gelinas, Jennifer; Giagante, Brenda; Henriquez-Ch, Rodrigo; Kander, Veena; Kochen, Silvia; Krysl, David; Martin, Kudr; Ikeda, Akio; Legnani, Mariana; Lin, Yicong; Martinez-Juarez, Iris; Muccioli, Lorenzo; Mwendaweli, Naluca; Oddo, Silvia; Özkara, Çigdem; Peixoto-Santos, José Eduardo; Perucca, Piero; Potschka, Heidrun; Rocha, Luisa; Scharfman, Helen; Scheffer, Ingrid; Surges, Rainer; Triki, Chanez Charfi; Uribe-San Martin, Reinaldo; Valente, Kette; van Vliet, Erwin; Wang, Yuping; Whatley, Benjamin; Wilmshurst, Jo; Yacubian, Elza Márcia; Rossi, Alessandro De; Curtis, Stefano de; Jiruska, Premysl; Henshall, David (2026) Epilepsia Open https://doi.org/10.1002/epi4.70282
Chris Greene, Declan Brennan, Sheida Mirloo, Ruairi Connolly, Jeffrey O'Callaghan, Avril Reddy, Jeff Henderson, Gergő Porkoláb, Adam McGlinchey, Nicole Hanley, Siobhan Hutchinson, James F M Meaney, Michael Farrel , Sarah L Doyl, Alon Friedman, Colin P Doherty, Matthew Campbell (2026) Sci Transl Med. 2026 Mar 18;18(841):eadu6037. doi: 10.1126/scitranslmed.adu6037. Epub 2026 Mar 18.
Yonatan Serlin, Hamza Imtiaz, Mark A. Maclean, Matthew W. Pease, David O. Okonkwo, Ava M. Puccio, Shawn Eagle, James F. Castellano, Sara K. Inati, Alon Friedman. (2026). Neurocritical Care. 44(1): 50-55. http://dx.doi.org/https://doi.org/10.1007/s12028-025-02282-5
2025
Lyna Kaminsky, Gerben van Hameren, Itai Weissberg , Pooyan Moradi, Ofer Prager, Alaa Abu Ahmad, Lior Schori, Albert Becker, Yaniv Zigel , Alon Friedman (2025) Epilepsia Open DOI: 10.1002/epi4.70070
Yonatan Serlin, Colyn Munn, Elisa A Ferrante, Lyna Kamintsky, Chantal Cousineau-Krieger, Edmond J. FitzGibbon, Camilo Toro, Sherrell Apugo, Alessandra Brofferio, M Luisa Iruela-Arispe, Alon Friedman, Manfred Boehm. (2025). Neurology Open Access. https://www.neurology.org/doi/full/10.1212/WN9.0000000000000069.
Nina Rebecca Held, Tobias Bauer, Rüdiger Stirnberg, Theda Von Der Recke, Nils Christian Lehnen, Tobias Baumgartner, Juri-Alexander Witt, Attila Rácz, Jan Pukropski, Lennart Walger, Randi Von Wrede, Mostafa Badr, David Wolf, Lennart Nils Kersting, Annalena Lange, Justus Bisten, Markus Schmidt, Eberhard Pracht, Daniel Löwen, Jennifer Faber, Christoph Helmstaedter, Martin Reuter, Alon Friedman, Alexander Radbruch, Rainer Surges, Tony Stöcker, Theodor Rüber (2025). eBioMedicine https://doi.org/10.1016/j.ebiom.2025.106040
Jamil H Muradov, Hannah Reid, Ellen Parker, Jackie Phinney, David B Clarke, Alon Friedman, Mark A MacLean (2025) Expert Rev Neurother Aug;25(8):991-1006. doi: 10.1080/14737175.2025.2524102. Epub 2025 Jun 29.
Jens P. Dreier, Svetlana Lublinsky, Viktor Horst, Sebastian Major, Coline L Lemale, Vasilis Kola, Maren K.L. Winkler, Eun-Jeung Kang, Karl Schoknecht, Nils Hecht, Anna Maslarova, Edgar Santos, Johannes Platz, Christina Kowoll, Oliver W Sakowitz, Erdem Güresir, Hartmut Vatter, Christian Dohmen, Stefan Wolf, Michael Scheel, Peter Vajkoczy, Jed A Hartings, Johannes Woitzik, Peter Martus, Alon Friedman. (2025). eBioMedicine. 1(1): 1-10. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00462-1/fulltext
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Imaging Blood-Brain Barrier Dysfunction in Drug-Resistant Epilepsy: A Multi-Center Feasibility Study
Nir Cafri, Sheida Mirloo, Daniel Zarhin, Lyna Kamintsky, Yonatan Serlin, Laith Alhadeed, Ilan Goldberg, Mark A. Maclean, Ben Whatley, Ilia Urman, Colin P. Doherty, Chris Greene, Claire Behan, Declan Brennan, Matthew Campbell, Chris Bowen, Gal Ben-Arie, Ilan Shelef, Britta Wandschneider, Matthias Koepp, Alon Friedman and Felix Benninger. (2025). Epilepsia. 66(1): 195-206. DOI: 10.1111/epi.18145.
Sarit Uzzan, Ira-Sivan Rostevanov, Ofer Prager, Haiat Nujedat, Jacob Kaplanski, Paul Picton, Alon Friedman, Abed N. Azab. (2025). Biomedicine & Pharmacotherapy. 192(118599): 1-15. http://dx.doi.org/doi.org/10.1016/j.biopha.2025.118599
Alon Friedman, Ofer Prager, Yonatan Serlin and Daniela Kaufer. (2025). Nature Reviews Neuroscience. (12):749-764 http://dx.doi.org/doi.org/10.1038/s41583-025-00976-5
S. Amara Ganon; A. Friedman; Y. Zigel. (2025). 47th Annual International Conference publication. :1-7. http://dx.doi.org/DOI:10.1109/EMBC58623.2025.11254025
Yonatan Serlin, Hamza Imtiaz, Tamir Avigdor, Anna Minarik, Sina Lash, Timothy Bardouille, Ben Whatley, Kristin M. Ikeda, Dan Z. Milikovsky, Sara K. Inati, Theodor Rüber, Rainer Surges, Attila Rácz, Alon Friedman. (2025). eBioMedicine.116(105780): 1-13. http://dx.doi.org/doi.org/10. 1016/j.ebiom.2025. 105780
Ryan S. Huang, Andrew Mihalache, Marko M. Popovic, Colyn Munn, Isabela Martins Melo, Aurora Pecaku, Alon Friedman, Miguel Cruz Pimentel, Tina Tang, Peng Yan, David T. Wong, Rajeev H. Muni. (2025). Retina. 45(6): 1125-1133. http://dx.doi.org/DOI:10.1097/IAE.0000000000004424
Andrew Malunga, Sina Lash, Alaa Abu-Ahmad, Laith Alhadeed, Felix Benninger, Gal Ben-Arie, Nicholas Fearns, Hamza Imtiaz, Stefan Kunst, Anna Minarik, Mutale Masamu, George Mshanga, Oliver Neal, Attila Racz, Theodor Ruber, Khalid Saadeh, Yonatan Serlin, Merav Shamir, Tamara Welte, Benjamin Whatley, Alon Friedman, Stanley Zimba. (2025). Epilepsia. (12):4869-4880. http://dx.doi.org/DOI: 10.1111/epi.18598
Yonatan Serlin, Hamza Imtiaz, Mark A. Maclean, Matthew W. Pease, David O. Okonkwo, Ava M. Puccio,Shawn Eagle, James F. Castellano, Sara K. Inati, Alon Friedman. Neurocritical Care.
Yonatan Serlin, Hamza Imtiaz, Tamir Avigdor, Anna Minarik, Sina Lash, Timothy Bardouille, Ben Whatley, Kristin M. Ikeda, Dan Z. Milikovsky, Sara K. Inati , Theodor Rüber , Rainer Surges , Attila Rácz, and Alon Friedman. eBioMedicine.116(105780): 1-13. http://dx.doi.org/doi.org/10. 1016/j.ebiom.2025. 105780.
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Imaging Blood-Brain Barrier Dysfunction in Drug-Resistant Epilepsy: A Multi-Center Feasibility Study
Nir Cafri, Sheida Mirloo, Daniel Zarhin, Lyna Kamintsky, Yonatan Serlin, Laith Alhadeed, Ilan Goldberg, Mark A. Maclean, Ben Whatley, Ilia Urman, Colin P. Doherty, Chris Greene, Claire Behan, Declan Brennan, Matthew Campbell, Chris Bowen, Gal Ben-Arie, Ilan Shelef, Britta Wandschneider, Matthias Koepp, Alon Friedman and Felix Benninger. Epilepsia.
Yonatan Serlin, Ryan S. Huang, Andrew Mihalache, Marko M. Popovic, Colyn Munn, Isabela Martins Melo, Aurora Pecaku, Alon Friedman, Miguel Cruz Pimentel, Tina Tang, Peng Yan, David T. Wong, Rajeev H. Muni, Retina.
2024
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Contrast Induced Encephalopathy and the Blood Brain Barrier
Maclean, M. A., Rogers, P. S., Muradov, J. H., Pickett, G. E., Friedman, A., Weeks, A., Greene, R., & Volders, D. The Canadian Journal of Neurological Sciences.
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Evidence for interictal blood-brain barrier dysfunction in people with epilepsy
Reiter, J. T., Schulte, F., Bauer, T., David, B., Endler, C., Isaak, A., Schuch, F., Bitzer, F., Witt, J.-A., Hattingen, E., Deichmann, R., Attenberger, U., Becker, A. J., Helmstaedter, C., Radbruch, A., Surges, R., Friedman, A., & Rüber, T. Epilepsia.
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Association of intravenous fluorescein angiography and adaptive optics imaging in diabetic retinopathy: A Prospective Case Series
Huang, R. S., Mihalache, A., Popovic, M. M., Munn, C., Balas, M., Issa, M., Melo, I. M., Friedman, A., Wright, T., Yan, P., & Muni, R. H. Retina.
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Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance
Power, L., Friedman, A., & Bardouille, T. Neurobiology of Aging.
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Transcranial Magnetic Stimulation Enhances the Therapeutic Effect of IGF-Trap in Intracerebral
Glioma Models
Stephanie Perrino, Udi Vazana , Ofer Prager, Lior Schori, Gal Ben-Arie, Anna Minarik, Yinhsuan Michely Chen, Orçun Haçariz, Masakazu Hashimoto, Yiftach Roth, Gabriel S. Pell, Alon Friedman and Pnina Brodt. Pharmaceuticals.
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Artificial Intelligence-Based Extraction of Quantitative Ultra-Widefield Fluorescein Angiography Parameters in Retinal Vein Occlusion
Ryan S. Huang, Andrew Mihalache, Marko M. Popovic, Colyn Munn, Isabela Martins Melo, Aurora Pecaku, Lyna Kamintsky, Alon Friedman, David T. Wong, Rajeev H. Muni. Canadian Journal of Ophthalmology.
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Interictal blood–brain barrier dysfunction in piriform cortex of people with epilepsy
Freya Schulte, Johannes T. Reiter, Tobias Bauer, Julia Taube, Felix Bitzer, Juri-Alexander Witt, Rory Piper, Anoja Thanabalasingam, Randi von Wrede, Attila Racz, Tobias Baumgartner, Valeri Borger, Louisa Specht-Riemenschneider, Hartmut Vatter, Elke Hattingen, Ralf Deichmann, Christoph Helmstaedter, Alexander Radbruch, Alon Friedman, Rainer Surges, Theodor Rüber. Annals of Clinical and Translational Neurology.
Gerben van Hameren, Refat Aboghazleh, Ellen Parker, Jens P. Dreier, Daniela Kaufer, Alon Friedman. Nature Reviews Neurology.
Pachter D, Kaplan A, Tsaban G, Zelicha H, Meir AY, Rinott E, Levakov G, Salti M, Yovell Y, Huhn S, Beyer F, Witte V, Kovacs P, von Bergen M, Ceglarek U, Blüher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I. Am J Clin Nutr.
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Artificial Intelligence-Enhanced Analysis of Retinal Vasculature in Age-Related Macular Degeneration
Huang, Ryan S.; Mihalache, Andrew; Popovic, Marko M., Munn, Colyn, Melo, Isabela Martins; Pecaku, Aurora; Friedman, Alon; Wong, David T., Muni, Rajeev H. Retina.
Guy Gurevitch, Nitzan Lubianiker, Taly Markovits, Ayelet Or-Borichev, Haggai Sharon, Naomi B Fine, Tom Fruchtman-Steinbok, Jacob N Keynan, Moni Shahar, Alon Friedman, Neomi Singer, Talma Hendler. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.
Erez Hanael, Shelly Baruch, Rotem Kalev Altman, Orit Chai, Kira Rapoport, Dana Peery, Alon Friedman,
Merav H. Shamir. Journal of Veterinary Internal Medicine.
Huang, Ryan S., Mihalache, Andrew, Popovic, Marko M., Munn, Colyn, Balas, Michael, Issa, Mariam,
Melo, Isabela Martins, Friedman, Alon, Wright, Tom, Yan, Peng, Muni, Rajeev H. RETINA.
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Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy
Tomkins-Netzer, O., Niederer, R., Greenwood, J., Fabian, I. D., Serlin, Y., Friedman, A., & Lightman, S. Progress in Retinal and Eye Research.
2023
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Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury
MacLean, M. A., Muradov, J. H., Greene, R., Van Hameren, G., Clarke, D. B., Dreier, J. P., Okonkwo, D. O., & Friedman, A.
Science Advances.
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Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Swissa, E., Monsonego, U., Yang, L. T., Schori, L., Kamintsky, L., Mirloo, S., Burger, I., Uzzan, S., Patel, R., Sudmant, P. H., Prager, O., Kaufer, D., & Friedman, A. eLife.
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Quantitative analysis of magnetic resonance images for characterization of blood-brain barrier dysfunction in dogs with brain tumors
Hanael, E., Baruch, S., Chai, O., Lishitsky, L., Blum, T., Rapoport, K., Ruggeri, M., Aizenberg, Z., Peery, D., Meyerhoff, N., Volk, H. A., De Decker, S., Tipold, A., Baumgaertner, W., Friedman, A., & Shamir, M. Journal of Veterinary Internal Medicine
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Neuro-psychiatric symptoms in directly and indirectly blast exposed civilian survivors of urban missile attacks
Saar-Ashkenazy, R., Naparstek, S., Dizitzer, Y., Zimhoni, N., Friedman, A., Shelef, I., Cohen, H., Shalev, H., Oxman, L., Novack, V., & Ifergane, G. BMC Psychiatry.
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Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury
van Hameren, G., Muradov, J., Minarik, A., Aboghazleh, R., Orr, S., Cort, S., Andrews, K., McKenna, C., Pham, N. T., MacLean, M. A., & Friedman, A. Neurobiology of Disease.
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Deep Isoflurane Anesthesia Is Associated with Alterations in Ion Homeostasis and Specific Na+/K+-ATPase Impairment in the Rat Brain
Reiffurth, C., Berndt, N., Gonzalez Lopez, A., Schoknecht, K., Kovács, R., Maechler, M., Grote Lambers, M., Dreier, J. P., Friedman, A., Spies, C., & Liotta, A. Anesthesiology.
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Blood-Brain Barrier Dysfunction and Exposure to Head Impacts in University Football Players
Jones, C. M. A., Kamintsky, L., Parker, E., Kureshi, N., Audas, L., Wilson, L., Champagne, A. A., Boulanger, M.-M., DiStefano, V., Fenerty, L., Bowen, C., Beyea, S., Atkinson, C., Clarke, D. B., & Friedman, A. Clinical Journal of Sport Medicine.
2022
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Stroke-prone salt-sensitive spontaneously hypertensive rats show higher susceptibility to spreading depolarization (SD) and altered hemodynamic responses to SD
Kang EJ, Prager O, Lublinsky S, Oliveria-Ferreira AI, Reiffurth C, Major S, Mueller DN, Friedman A, Dreier, JP. Journal of Cerebral Blood Flow and Metabolism.
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White‐matter correlates of anxiety: The contribution of the corpus‐callosum to the study of anxiety and stress‐related disorders
Saar‐Ashkenazy R, Guez J, Jacob Y, Veksler R, Cohen JE, Shelef I, Friedman A, & Benifla M. International Journal of Methods in Psychiatric Research.
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A companion to the preclinical common data elements and case report forms for in vivo rodent Neuroimaging. A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force
Van Vliet, E. A., Immonen, R., Prager, O., Friedman, A., Bankstahl, J. P., Wright, D. K., O’Brien, T. J., Potschka, H., Gröhn, O., & Harris, N. G. Epilepsia Open.
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Telmisartan as an add-on treatment for dogs with refractory idiopathic epilepsy: A nonrandomized, uncontrolled, open-label clinical trial
Hanael, E., Chai, O., Konstanitin, L., Gibeon, L., Rapaport, K., Ruggeri, M., Friedman, A., & Shamir, M. H. Journal of the American Veterinary Medical Association.
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International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra, N. K., Engel, J., Liebeskind, D. S., Sharma, V. K., Hirsch, L. J., Kasner, S. E., French, J. A., Devinsky, O., Friedman, A., Dawson, J., Quinn, T. J., Selim, M., de Havenon, A., Yasuda, C. L., Cendes, F., Benninger, F., Zaveri, H. P., Burneo, J. G., Srivastava, P., … Kwan, P. Epilepsy & Behavior.
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Reversal of insulin resistance is associated with repair of blood–brain barrier dysfunction and remission in a patient with treatment-resistant bipolar depression.
Calkin, C., Kamintsky, L., & Friedman, A. Bipolar Disorders.
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Detection of blood-brain barrier dysfunction using advanced imaging methods to predict seizures in dogs with meningoencephalitis of unknown origin
Hanael, E., Baruch, S., Chai, O., Nir, Z., Rapoport, K., Ruggeri, M., Eizenberg, I., Peery, D., Friedman, A., & Shamir, M. H. Journal of Veterinary Internal Medicine.
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Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study.
Dreier, J. P., Winkler, M. K. L., Major, S., Horst, V., Lublinsky, S., Kola, V., Lemale, C. L., Kang, E.-J., Maslarova, A., Salur, I., Lückl, J., Platz, J., Jorks, D., Oliveira-Ferreira, A. I., Schoknecht, K., Reiffurth, C., Milakara, D., Wiesenthal, D., Hecht, N., … Woitzik, J. Brain.
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Craniotomy for acute monitoring of pial vessels in the rodent brain
Aboghazleh, R., Alkahmous, B., Swissa, E., Mansoor, S., Friedman, A., & Prager, O. MethodsX.
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Symptoms reported by Canadians posted in Havana are linked with reduced white matter fibre density
Aristi, G., Kamintsky, L., Ross, M., Bowen, C., Calkin, C., Friedman, A., & Hashmi, J. A. Brain Communications.
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A fluorescein angiography-based computer-aided algorithm for assessing the retinal vasculature in diabetic retinopathy
Abbasnejad, A., Tomkins-Netzer, O., Winter, A., Friedman, A., Cruess, A., Serlin, Y., & Levy, J. Eye.
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Resting state functional connectivity in SLE patients and association with cognitive impairment and blood–brain barrier permeability
Hanly, J. G., Robertson, J. W., Legge, A., Kamintsky, L., Aristi, G., Friedman, A., Beyea, S. D., Fisk, J. D., Omisade, A., Calkin, C., Bardouille, T., Bowen, C., Matheson, K., & Hashmi, J. A. Rheumatology.
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Role of autoantibodies and blood–brain barrier leakage in cognitive impairment in systemic lupus erythematosus
Hanly, J. G., Legge, A., Kamintsky, L., Friedman, A., Hashmi, J. A., Beyea, S. D., Fisk, J., Omisade, A., Calkin, C., Bardouille, T., Bowen, C., Matheson, K., & Fritzler, M. J. Lupus Science & Medicine.
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The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: The Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
Kaplan, A., Zelicha, H., Yaskolka Meir, A., Rinott, E., Tsaban, G., Levakov, G., Prager, O., Salti, M., Yovell, Y., Ofer, J., Huhn, S., Beyer, F., Witte, V., Villringer, A., Meiran, N., B Emesh, T., Kovacs, P., von Bergen, M., Ceglarek, U., … Shai, I. The American Journal of Clinical Nutrition.
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Paroxysmal slow wave events predict epilepsy following a first seizure
Zelig, D., Goldberg, I., Shor, O., Ben Dor, S., Yaniv-Rosenfeld, A., Milikovsky, D. Z., Ofer, J., Imtiaz, H., Friedman, A., & Benninger, F. Epilepsia.
2021
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Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction
Parker, E., Aboghazleh, R., Mumby, G., Veksler, R., Ofer, J., Newton, J., Smith, R., Kamintsky, L., Jones, C. M. A., O’Keeffe, E., Kelly, E., Doelle, K., Roach, I., Yang, L. T., Moradi, P., Lin, J. M., Gleason, A. J., Atkinson, C., Bowen, C., … Friedman, A. Brain.
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Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model
Aboghazleh, R., Parker, E., Yang, L. T., Kaufer, D., Dreier, J. P., Friedman, A., & van Hameren, G. International Journal of Molecular Sciences.
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Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder
Calkin, C., McClelland, C., Cairns, K., Kamintsky, L., & Friedman, A. Frontiers in Psychiatry.
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Distorted Optic Nerve Portends Neurological Complications in Infants With External Hydrocephalus.
Serlin, Y., Ben-Arie, G., Lublinsky, S., Flusser, H., Friedman, A., & Shelef, I. Frontiers in Neurology.
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The role of spreading depolarizations and electrographic seizures in early injury progression of the rat photothrombosis stroke model.
Schoknecht, K., Kikhia, M., Lemale, C. L., Liotta, A., Lublinsky, S., Mueller, S., Boehm-Sturm, P., Friedman, A., & Dreier, J. P. Journal of Cerebral Blood Flow & Metabolism.
2020
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The potential role of microvascular pathology in the neurological manifestations of coronavirus infection.
MacLean, M. A., Kamintsky, L., Leck, E. D., & Friedman, A. Fluids and Barriers of the CNS.
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Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment.
Kamintsky, L., Beyea, S. D., Fisk, J. D., Hashmi, J. A., Omisade, A., Calkin, C., Bardouille, T., Bowen, C., Quraan, M., Mitnitski, A., Matheson, K., Friedman, A., & Hanly, J. G. Annals of the Rheumatic Diseases.
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Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient’s glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.
Levite, M., Zelig, D., Friedman, A., Ilouz, N., Eilam, R., Bromberg, Z., Ramadhan Lasu, A. A., Arbel-Alon, S., Edvardson, S., Tarshish, M., Riek, L. P., Lako, R. L., Reubinoff, B., Lebendiker, M., Yaish, D., Stavsky, A., & Galun, E. Journal of Autoimmunity.
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Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?
Löscher, W., & Friedman, A. International Journal of Molecular Sciences.
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Midazolam and isoflurane combination reduces late brain damage in the paraoxon-induced status epilepticus rat model.
Swissa, E., Bar-Klein, G., Serlin, Y., Weissberg, I., Kamintsky, L., Eisenkraft, A., Statlender, L., Shrot, S., Rosman, Y., Prager, O., & Friedman, A. Neurotoxicology.
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Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.
Veksler, R., Vazana, U., Serlin, Y., Prager, O., Ofer, J., Shemen, N., Fisher, A. M., Minaeva, O., Hua, N., Saar-Ashkenazy, R., Benou, I., Riklin-Raviv, T., Parker, E., Mumby, G., Kamintsky, L., Beyea, S., Bowen, C. V., Shelef, I., O’Keeffe, E., … Friedman, A. Brain: A Journal of Neurology.
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TMS-Induced Controlled BBB Opening: Preclinical Characterization and Implications for Treatment of Brain Cancer.
Vazana, U., Schori, L., Monsonego, U., Swissa, E., Pell, G. S., Roth, Y., Brodt, P., Friedman, A., & Prager, O. Pharmaceutics.
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Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
Klein, P., Friedman, A., Hameed, M. Q., Kaminski, R. M., Bar‐Klein, G., Klitgaard, H., Koepp, M., Jozwiak, S., Prince, D. A., Rotenberg, A., Twyman, R., Vezzani, A., Wong, M., & Löscher, W. Epilepsia.
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Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression.
Kamintsky, L., Cairns, K. A., Veksler, R., Bowen, C., Beyea, S. D., Friedman, A., & Calkin, C. NeuroImage: Clinical, 26, 102049.
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Victims of war-Psychoendocrine evidence for the impact of traumatic stress on psychological well-being of adolescents growing up during the Israeli-Palestinian conflict.
Shaheen, M., Schindler, L., Saar-Ashkenazy, R., Bani Odeh, K., Soreq, H., Friedman, A., & Kirschbaum, C. Psychophysiology.
2019
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Changes of dimension of EEG/ECoG nonlinear dynamics predict epileptogenesis and therapy outcomes.
Rizzi, M., Brandt, C., Weissberg, I., Milikovsky, D. Z., Pauletti, A., Terrone, G., Salamone, A., Frigerio, F., Löscher, W., Friedman, A., & Vezzani, A. (2019). Neurobiology of Disease, 124, 373–378.
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Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.
Senatorov, V. V., Friedman, A. R., Milikovsky, D. Z., Ofer, J., Saar-Ashkenazy, R., Charbash, A., Jahan, N., Chin, G., Mihaly, E., Lin, J. M., Ramsay, H. J., Moghbel, A., Preininger, M. K., Eddings, C. R., Harrison, H. V., Patel, R., Shen, Y., Ghanim, H., Sheng, H., … Kaufer, D. Science Translational Medicine.
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Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage.
Lublinsky, S., Major, S., Kola, V., Horst, V., Santos, E., Platz, J., Sakowitz, O., Scheel, M., Dohmen, C., Graf, R., Vatter, H., Wolf, S., Vajkoczy, P., Shelef, I., Woitzik, J., Martus, P., Dreier, J. P., & Friedman, A. EBioMedicine, 43, 460–472.
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Combining white matter diffusion and geometry for tract-specific alignment and variability analysis.
Benou, I., Veksler, R., Friedman, A., & Raviv, T. R. NeuroImage.
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Blood-brain barrier dysfunction in canine epileptic seizures detected by dynamic contrast-enhanced magnetic resonance imaging.
Hanael, E., Veksler, R., Friedman, A., Bar-Klein, G., Senatorov, V. V., Kaufer, D., Konstantin, L., Elkin, M., Chai, O., Peery, D., & Shamir, M. H. Epilepsia.
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Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis.
Swissa, E., Serlin, Y., Vazana, U., Prager, O., & Friedman, A. Epilepsy & Behavior.
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Blood-Brain Barrier Leakage: A New Biomarker in Transient Ischemic Attacks.
Serlin, Y., Ofer, J., Ben-Arie, G., Veksler, R., Ifergane, G., Shelef, I., Minuk, J., Horev, A., & Friedman, A. Stroke.
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Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction.
Prager, O., Kamintsky, L., Hasam-Henderson, L. A., Schoknecht, K., Wuntke, V., Papageorgiou, I., Swolinsky, J., Muoio, V., Bar-Klein, G., Vazana, U., Heinemann, U., Friedman, A., & Kovács, R. Epilepsia.
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Paroxysmal slow cortical activity in Alzheimer’s disease and epilepsy is associated with blood-brain barrier dysfunction.
Milikovsky, D. Z., Ofer, J., Senatorov, V. V., Friedman, A. R., Prager, O., Sheintuch, L., Elazari, N., Veksler, R., Zelig, D., Weissberg, I., Bar-Klein, G., Swissa, E., Hanael, E., Ben-Arie, G., Schefenbauer, O., Kamintsky, L., Saar-Ashkenazy, R., Shelef, I., Shamir, M. H., … Friedman, A. Science Translational Medicine.
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Victims of War: Dehydroepiandrosterone Concentrations in Hair and Their Associations with Trauma Sequelae in Palestinian Adolescents Living in the West Bank.
Schindler, L., Shaheen, M., Saar-Ashkenazy, R., Bani Odeh, K., Sass, S.-H., Friedman, A., & Kirschbaum, C. Brain Sciences.
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Havana Syndrome Among Canadian Diplomats: Brain Imaging Reveals Acquired Neurotoxicity.
Friedman, A., Calkin, C., Adams, A., Suarez, G. A., Bardouille, T., Hacohen, N., Green, A. L., Gupta, R. R., Hashmi, J., Kamintsky, L., Kim, J. S., Laroche, R., MacKenzie, D., Milikovsky, D., Oystreck, D., Newton, J., Noel, G., Ofer, J., Quraan, M., … Bowen, C. MedRxiv.
2018
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Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Tagge, C. A., Fisher, A. M., Minaeva, O. V., Gaudreau-Balderrama, A., Moncaster, J. A., Zhang, X.-L., Wojnarowicz, M. W., Casey, N., Lu, H., Kokiko-Cochran, O. N., Saman, S., Ericsson, M., Onos, K. D., Veksler, R., Senatorov, V. V., Kondo, A., Zhou, X. Z., Miry, O., Vose, L. R., … Goldstein, L. E. (2018). Brain: A Journal of Neurology.
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Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke.
Dreier, J. P., Lemale, C. L., Kola, V., Friedman, A., & Schoknecht, K. Neuropharmacology.
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Evidence for peri-ictal blood–brain barrier dysfunction in patients with epilepsy.
Rüber, T., David, B., Lüchters, G., Nass, R. D., Friedman, A., Surges, R., Stöcker, T., Weber, B., Deichmann, R., Schlaug, G., Hattingen, E., & Elger, C. E. Brain.
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Bioenergetic Mechanisms of Seizure Control.
Kovács, R., Gerevich, Z., Friedman, A., Otáhal, J., Prager, O., Gabriel, S., & Berndt, N. Frontiers in Cellular Neuroscience.
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Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?
Scharfman, H. E., Kanner, A. M., Friedman, A., Blümcke, I., Crocker, C. E., Cendes, F., Diaz-Arrastia, R., Förstl, H., Fenton, A. A., Grace, A. A., Palop, J., Morrison, J., Nehlig, A., Prasad, A., Wilcox, K. S., Jette, N., & Pohlmann-Eden, B.
2017
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Simulation of spreading depolarization trajectories in cerebral cortex: Correlation of velocity and susceptibility in patients with aneurysmal subarachnoid hemorrhage.
Milakara, D., Grozea, C., Dahlem, M., Major, S., Winkler, M. K. L., Lückl, J., Scheel, M., Kola, V., Schoknecht, K., Lublinsky, S., Friedman, A., Martus, P., Hartings, J. A., Woitzik, J., & Dreier, J. P. NeuroImage. Clinical.
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Electrocorticographic Dynamics as a Novel Biomarker in Five Models of Epileptogenesis.
Milikovsky, D. Z., Weissberg, I., Kamintsky, L., Lippmann, K., Schefenbauer, O., Frigerio, F., Rizzi, M., Sheintuch, L., Zelig, D., Ofer, J., Vezzani, A., & Friedman, A. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience.
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TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults.
Kim, S. Y., Senatorov, V. V., Morrissey, C. S., Lippmann, K., Vazquez, O., Milikovsky, D. Z., Gu, F., Parada, I., Prince, D. A., Becker, A. J., Heinemann, U., Friedman, A., & Kaufer, D. Scientific Reports.
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Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.
Bekenstein, U., Mishra, N., Milikovsky, D. Z., Hanin, G., Zelig, D., Sheintuch, L., Berson, A., Greenberg, D. S., Friedman, A., & Soreq, H. Proceedings of the National Academy of Sciences of the United States of America.
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Role of neural barriers in the pathogenesis and outcome of Streptococcus pneumoniae meningitis.
Prager, O., Friedman, A., & Nebenzahl, Y. M. Experimental and Therapeutic Medicine.
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Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro.
Schoknecht, K., Berndt, N., Rösner, J., Heinemann, U., Dreier, J. P., Kovács, R., Friedman, A., & Liotta, A. International Journal of Molecular Sciences.
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Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.
Bekenstein, U., Mishra, N., Milikovsky, D. Z., Hanin, G., Zelig, D., Sheintuch, L., Berson, A., Greenberg, D. S., Friedman, A., & Soreq, H. Proceedings of the National Academy of Sciences.
2016
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Automated Cross-Sectional Measurement Method of Intracranial Dural Venous Sinuses.
Lublinsky, S., Friedman, A., Kesler, A., Zur, D., Anconina, R., & Shelef, I. AJNR. American Journal of Neuroradiology.
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Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses
Soreq, H., Friedman, A., & Kaufer, D. Wiley-Blackwell.