Recent Publications

2024

Contrast Induced Encephalopathy and the Blood Brain Barrier
Maclean, M. A., Rogers, P. S., Muradov, J. H., Pickett, G. E., Friedman, A., Weeks, A., Greene, R., & Volders, D. The Canadian Journal of Neurological Sciences.
Evidence for interictal blood-brain barrier dysfunction in people with epilepsy
Reiter, J. T., Schulte, F., Bauer, T., David, B., Endler, C., Isaak, A., Schuch, F., Bitzer, F., Witt, J.-A., Hattingen, E., Deichmann, R., Attenberger, U., Becker, A. J., Helmstaedter, C., Radbruch, A., Surges, R., Friedman, A., & Rüber, T. Epilepsia.
Association of intravenous fluorescein angiography and adaptive optics imaging in diabetic retinopathy: A Prospective Case Series
Huang, R. S., Mihalache, A., Popovic, M. M., Munn, C., Balas, M., Issa, M., Melo, I. M., Friedman, A., Wright, T., Yan, P., & Muni, R. H. Retina.
Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance
Power, L., Friedman, A., & Bardouille, T. Neurobiology of Aging.
Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy
Tomkins-Netzer, O., Niederer, R., Greenwood, J., Fabian, I. D., Serlin, Y., Friedman, A., & Lightman, S. Progress in Retinal and Eye Research.

2023

Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury
MacLean, M. A., Muradov, J. H., Greene, R., Van Hameren, G., Clarke, D. B., Dreier, J. P., Okonkwo, D. O., & Friedman, A.
Science Advances.
Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Swissa, E., Monsonego, U., Yang, L. T., Schori, L., Kamintsky, L., Mirloo, S., Burger, I., Uzzan, S., Patel, R., Sudmant, P. H., Prager, O., Kaufer, D., & Friedman, A. eLife.
Quantitative analysis of magnetic resonance images for characterization of blood-brain barrier dysfunction in dogs with brain tumors
Hanael, E., Baruch, S., Chai, O., Lishitsky, L., Blum, T., Rapoport, K., Ruggeri, M., Aizenberg, Z., Peery, D., Meyerhoff, N., Volk, H. A., De Decker, S., Tipold, A., Baumgaertner, W., Friedman, A., & Shamir, M. Journal of Veterinary Internal Medicine
Neuro-psychiatric symptoms in directly and indirectly blast exposed civilian survivors of urban missile attacks
Saar-Ashkenazy, R., Naparstek, S., Dizitzer, Y., Zimhoni, N., Friedman, A., Shelef, I., Cohen, H., Shalev, H., Oxman, L., Novack, V., & Ifergane, G. BMC Psychiatry.
Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury
van Hameren, G., Muradov, J., Minarik, A., Aboghazleh, R., Orr, S., Cort, S., Andrews, K., McKenna, C., Pham, N. T., MacLean, M. A., & Friedman, A. Neurobiology of Disease.
Deep Isoflurane Anesthesia Is Associated with Alterations in Ion Homeostasis and Specific Na+/K+-ATPase Impairment in the Rat Brain
Reiffurth, C., Berndt, N., Gonzalez Lopez, A., Schoknecht, K., Kovács, R., Maechler, M., Grote Lambers, M., Dreier, J. P., Friedman, A., Spies, C., & Liotta, A. Anesthesiology.
Blood-Brain Barrier Dysfunction and Exposure to Head Impacts in University Football Players
Jones, C. M. A., Kamintsky, L., Parker, E., Kureshi, N., Audas, L., Wilson, L., Champagne, A. A., Boulanger, M.-M., DiStefano, V., Fenerty, L., Bowen, C., Beyea, S., Atkinson, C., Clarke, D. B., & Friedman, A. Clinical Journal of Sport Medicine.

2022

Stroke-prone salt-sensitive spontaneously hypertensive rats show higher susceptibility to spreading depolarization (SD) and altered hemodynamic responses to SD
Kang EJ, Prager O, Lublinsky S, Oliveria-Ferreira AI, Reiffurth C, Major S, Mueller DN, Friedman A, Dreier, JP. Journal of Cerebral Blood Flow and Metabolism.
White‐matter correlates of anxiety: The contribution of the corpus‐callosum to the study of anxiety and stress‐related disorders
Saar‐Ashkenazy R, Guez J, Jacob Y, Veksler R, Cohen JE, Shelef I, Friedman A, & Benifla M. International Journal of Methods in Psychiatric Research.
A companion to the preclinical common data elements and case report forms for in vivo rodent Neuroimaging. A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force
Van Vliet, E. A., Immonen, R., Prager, O., Friedman, A., Bankstahl, J. P., Wright, D. K., O’Brien, T. J., Potschka, H., Gröhn, O., & Harris, N. G. Epilepsia Open.
Telmisartan as an add-on treatment for dogs with refractory idiopathic epilepsy: A nonrandomized, uncontrolled, open-label clinical trial
Hanael, E., Chai, O., Konstanitin, L., Gibeon, L., Rapaport, K., Ruggeri, M., Friedman, A., & Shamir, M. H. Journal of the American Veterinary Medical Association.
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra, N. K., Engel, J., Liebeskind, D. S., Sharma, V. K., Hirsch, L. J., Kasner, S. E., French, J. A., Devinsky, O., Friedman, A., Dawson, J., Quinn, T. J., Selim, M., de Havenon, A., Yasuda, C. L., Cendes, F., Benninger, F., Zaveri, H. P., Burneo, J. G., Srivastava, P., … Kwan, P. Epilepsy & Behavior.

Reversal of insulin resistance is associated with repair of blood–brain barrier dysfunction and remission in a patient with treatment-resistant bipolar depression.
Calkin, C., Kamintsky, L., & Friedman, A. Bipolar Disorders.
Detection of blood-brain barrier dysfunction using advanced imaging methods to predict seizures in dogs with meningoencephalitis of unknown origin
Hanael, E., Baruch, S., Chai, O., Nir, Z., Rapoport, K., Ruggeri, M., Eizenberg, I., Peery, D., Friedman, A., & Shamir, M. H. Journal of Veterinary Internal Medicine.
Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study.
Dreier, J. P., Winkler, M. K. L., Major, S., Horst, V., Lublinsky, S., Kola, V., Lemale, C. L., Kang, E.-J., Maslarova, A., Salur, I., Lückl, J., Platz, J., Jorks, D., Oliveira-Ferreira, A. I., Schoknecht, K., Reiffurth, C., Milakara, D., Wiesenthal, D., Hecht, N., … Woitzik, J. Brain.
Craniotomy for acute monitoring of pial vessels in the rodent brain
Aboghazleh, R., Alkahmous, B., Swissa, E., Mansoor, S., Friedman, A., & Prager, O. MethodsX.
Symptoms reported by Canadians posted in Havana are linked with reduced white matter fibre density
Aristi, G., Kamintsky, L., Ross, M., Bowen, C., Calkin, C., Friedman, A., & Hashmi, J. A. Brain Communications.

A fluorescein angiography-based computer-aided algorithm for assessing the retinal vasculature in diabetic retinopathy
Abbasnejad, A., Tomkins-Netzer, O., Winter, A., Friedman, A., Cruess, A., Serlin, Y., & Levy, J. Eye.

Resting state functional connectivity in SLE patients and association with cognitive impairment and blood–brain barrier permeability
Hanly, J. G., Robertson, J. W., Legge, A., Kamintsky, L., Aristi, G., Friedman, A., Beyea, S. D., Fisk, J. D., Omisade, A., Calkin, C., Bardouille, T., Bowen, C., Matheson, K., & Hashmi, J. A. Rheumatology.

Role of autoantibodies and blood–brain barrier leakage in cognitive impairment in systemic lupus erythematosus
Hanly, J. G., Legge, A., Kamintsky, L., Friedman, A., Hashmi, J. A., Beyea, S. D., Fisk, J., Omisade, A., Calkin, C., Bardouille, T., Bowen, C., Matheson, K., & Fritzler, M. J. Lupus Science & Medicine.

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: The Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
Kaplan, A., Zelicha, H., Yaskolka Meir, A., Rinott, E., Tsaban, G., Levakov, G., Prager, O., Salti, M., Yovell, Y., Ofer, J., Huhn, S., Beyer, F., Witte, V., Villringer, A., Meiran, N., B Emesh, T., Kovacs, P., von Bergen, M., Ceglarek, U., … Shai, I. The American Journal of Clinical Nutrition.
Paroxysmal slow wave events predict epilepsy following a first seizure
Zelig, D., Goldberg, I., Shor, O., Ben Dor, S., Yaniv-Rosenfeld, A., Milikovsky, D. Z., Ofer, J., Imtiaz, H., Friedman, A., & Benninger, F. Epilepsia.

2021

Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction
Parker, E., Aboghazleh, R., Mumby, G., Veksler, R., Ofer, J., Newton, J., Smith, R., Kamintsky, L., Jones, C. M. A., O’Keeffe, E., Kelly, E., Doelle, K., Roach, I., Yang, L. T., Moradi, P., Lin, J. M., Gleason, A. J., Atkinson, C., Bowen, C., … Friedman, A. Brain.
Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model
Aboghazleh, R., Parker, E., Yang, L. T., Kaufer, D., Dreier, J. P., Friedman, A., & van Hameren, G. International Journal of Molecular Sciences.
Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder
Calkin, C., McClelland, C., Cairns, K., Kamintsky, L., & Friedman, A. Frontiers in Psychiatry.

Distorted Optic Nerve Portends Neurological Complications in Infants With External Hydrocephalus.
Serlin, Y., Ben-Arie, G., Lublinsky, S., Flusser, H., Friedman, A., & Shelef, I. Frontiers in Neurology.

The role of spreading depolarizations and electrographic seizures in early injury progression of the rat photothrombosis stroke model.
Schoknecht, K., Kikhia, M., Lemale, C. L., Liotta, A., Lublinsky, S., Mueller, S., Boehm-Sturm, P., Friedman, A., & Dreier, J. P. Journal of Cerebral Blood Flow & Metabolism.

2020

The potential role of microvascular pathology in the neurological manifestations of coronavirus infection.
MacLean, M. A., Kamintsky, L., Leck, E. D., & Friedman, A. Fluids and Barriers of the CNS.

Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment.
Kamintsky, L., Beyea, S. D., Fisk, J. D., Hashmi, J. A., Omisade, A., Calkin, C., Bardouille, T., Bowen, C., Quraan, M., Mitnitski, A., Matheson, K., Friedman, A., & Hanly, J. G. Annals of the Rheumatic Diseases.

Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient’s glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.
Levite, M., Zelig, D., Friedman, A., Ilouz, N., Eilam, R., Bromberg, Z., Ramadhan Lasu, A. A., Arbel-Alon, S., Edvardson, S., Tarshish, M., Riek, L. P., Lako, R. L., Reubinoff, B., Lebendiker, M., Yaish, D., Stavsky, A., & Galun, E. Journal of Autoimmunity.

Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?
Löscher, W., & Friedman, A. International Journal of Molecular Sciences.

Midazolam and isoflurane combination reduces late brain damage in the paraoxon-induced status epilepticus rat model.
Swissa, E., Bar-Klein, G., Serlin, Y., Weissberg, I., Kamintsky, L., Eisenkraft, A., Statlender, L., Shrot, S., Rosman, Y., Prager, O., & Friedman, A. Neurotoxicology.

Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.
Veksler, R., Vazana, U., Serlin, Y., Prager, O., Ofer, J., Shemen, N., Fisher, A. M., Minaeva, O., Hua, N., Saar-Ashkenazy, R., Benou, I., Riklin-Raviv, T., Parker, E., Mumby, G., Kamintsky, L., Beyea, S., Bowen, C. V., Shelef, I., O’Keeffe, E., … Friedman, A. Brain: A Journal of Neurology.

TMS-Induced Controlled BBB Opening: Preclinical Characterization and Implications for Treatment of Brain Cancer.
Vazana, U., Schori, L., Monsonego, U., Swissa, E., Pell, G. S., Roth, Y., Brodt, P., Friedman, A., & Prager, O. Pharmaceutics.

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
Klein, P., Friedman, A., Hameed, M. Q., Kaminski, R. M., Bar‐Klein, G., Klitgaard, H., Koepp, M., Jozwiak, S., Prince, D. A., Rotenberg, A., Twyman, R., Vezzani, A., Wong, M., & Löscher, W. Epilepsia.

Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression.
Kamintsky, L., Cairns, K. A., Veksler, R., Bowen, C., Beyea, S. D., Friedman, A., & Calkin, C. NeuroImage: Clinical, 26, 102049.

Victims of war-Psychoendocrine evidence for the impact of traumatic stress on psychological well-being of adolescents growing up during the Israeli-Palestinian conflict.
Shaheen, M., Schindler, L., Saar-Ashkenazy, R., Bani Odeh, K., Soreq, H., Friedman, A., & Kirschbaum, C. Psychophysiology.

2019

Changes of dimension of EEG/ECoG nonlinear dynamics predict epileptogenesis and therapy outcomes.
Rizzi, M., Brandt, C., Weissberg, I., Milikovsky, D. Z., Pauletti, A., Terrone, G., Salamone, A., Frigerio, F., Löscher, W., Friedman, A., & Vezzani, A. (2019). Neurobiology of Disease, 124, 373–378.

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.
Senatorov, V. V., Friedman, A. R., Milikovsky, D. Z., Ofer, J., Saar-Ashkenazy, R., Charbash, A., Jahan, N., Chin, G., Mihaly, E., Lin, J. M., Ramsay, H. J., Moghbel, A., Preininger, M. K., Eddings, C. R., Harrison, H. V., Patel, R., Shen, Y., Ghanim, H., Sheng, H., … Kaufer, D. Science Translational Medicine.

Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage.
Lublinsky, S., Major, S., Kola, V., Horst, V., Santos, E., Platz, J., Sakowitz, O., Scheel, M., Dohmen, C., Graf, R., Vatter, H., Wolf, S., Vajkoczy, P., Shelef, I., Woitzik, J., Martus, P., Dreier, J. P., & Friedman, A. EBioMedicine, 43, 460–472.

Combining white matter diffusion and geometry for tract-specific alignment and variability analysis.
Benou, I., Veksler, R., Friedman, A., & Raviv, T. R. NeuroImage.

Blood-brain barrier dysfunction in canine epileptic seizures detected by dynamic contrast-enhanced magnetic resonance imaging.
Hanael, E., Veksler, R., Friedman, A., Bar-Klein, G., Senatorov, V. V., Kaufer, D., Konstantin, L., Elkin, M., Chai, O., Peery, D., & Shamir, M. H. Epilepsia.

Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis.
Swissa, E., Serlin, Y., Vazana, U., Prager, O., & Friedman, A. Epilepsy & Behavior.

Blood-Brain Barrier Leakage: A New Biomarker in Transient Ischemic Attacks.
Serlin, Y., Ofer, J., Ben-Arie, G., Veksler, R., Ifergane, G., Shelef, I., Minuk, J., Horev, A., & Friedman, A. Stroke.

Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction.
Prager, O., Kamintsky, L., Hasam-Henderson, L. A., Schoknecht, K., Wuntke, V., Papageorgiou, I., Swolinsky, J., Muoio, V., Bar-Klein, G., Vazana, U., Heinemann, U., Friedman, A., & Kovács, R. Epilepsia.

Paroxysmal slow cortical activity in Alzheimer’s disease and epilepsy is associated with blood-brain barrier dysfunction.
Milikovsky, D. Z., Ofer, J., Senatorov, V. V., Friedman, A. R., Prager, O., Sheintuch, L., Elazari, N., Veksler, R., Zelig, D., Weissberg, I., Bar-Klein, G., Swissa, E., Hanael, E., Ben-Arie, G., Schefenbauer, O., Kamintsky, L., Saar-Ashkenazy, R., Shelef, I., Shamir, M. H., … Friedman, A. Science Translational Medicine.

Victims of War: Dehydroepiandrosterone Concentrations in Hair and Their Associations with Trauma Sequelae in Palestinian Adolescents Living in the West Bank.
Schindler, L., Shaheen, M., Saar-Ashkenazy, R., Bani Odeh, K., Sass, S.-H., Friedman, A., & Kirschbaum, C. Brain Sciences.

Havana Syndrome Among Canadian Diplomats: Brain Imaging Reveals Acquired Neurotoxicity.
Friedman, A., Calkin, C., Adams, A., Suarez, G. A., Bardouille, T., Hacohen, N., Green, A. L., Gupta, R. R., Hashmi, J., Kamintsky, L., Kim, J. S., Laroche, R., MacKenzie, D., Milikovsky, D., Oystreck, D., Newton, J., Noel, G., Ofer, J., Quraan, M., … Bowen, C. MedRxiv.

2018

Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Tagge, C. A., Fisher, A. M., Minaeva, O. V., Gaudreau-Balderrama, A., Moncaster, J. A., Zhang, X.-L., Wojnarowicz, M. W., Casey, N., Lu, H., Kokiko-Cochran, O. N., Saman, S., Ericsson, M., Onos, K. D., Veksler, R., Senatorov, V. V., Kondo, A., Zhou, X. Z., Miry, O., Vose, L. R., … Goldstein, L. E. (2018). Brain: A Journal of Neurology.

Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke.
Dreier, J. P., Lemale, C. L., Kola, V., Friedman, A., & Schoknecht, K. Neuropharmacology.

Evidence for peri-ictal blood–brain barrier dysfunction in patients with epilepsy.
Rüber, T., David, B., Lüchters, G., Nass, R. D., Friedman, A., Surges, R., Stöcker, T., Weber, B., Deichmann, R., Schlaug, G., Hattingen, E., & Elger, C. E. Brain.

Bioenergetic Mechanisms of Seizure Control.
Kovács, R., Gerevich, Z., Friedman, A., Otáhal, J., Prager, O., Gabriel, S., & Berndt, N. Frontiers in Cellular Neuroscience.

Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?
Scharfman, H. E., Kanner, A. M., Friedman, A., Blümcke, I., Crocker, C. E., Cendes, F., Diaz-Arrastia, R., Förstl, H., Fenton, A. A., Grace, A. A., Palop, J., Morrison, J., Nehlig, A., Prasad, A., Wilcox, K. S., Jette, N., & Pohlmann-Eden, B.

2017

Simulation of spreading depolarization trajectories in cerebral cortex: Correlation of velocity and susceptibility in patients with aneurysmal subarachnoid hemorrhage.
Milakara, D., Grozea, C., Dahlem, M., Major, S., Winkler, M. K. L., Lückl, J., Scheel, M., Kola, V., Schoknecht, K., Lublinsky, S., Friedman, A., Martus, P., Hartings, J. A., Woitzik, J., & Dreier, J. P. NeuroImage. Clinical.

Electrocorticographic Dynamics as a Novel Biomarker in Five Models of Epileptogenesis.
Milikovsky, D. Z., Weissberg, I., Kamintsky, L., Lippmann, K., Schefenbauer, O., Frigerio, F., Rizzi, M., Sheintuch, L., Zelig, D., Ofer, J., Vezzani, A., & Friedman, A. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience.

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults.
Kim, S. Y., Senatorov, V. V., Morrissey, C. S., Lippmann, K., Vazquez, O., Milikovsky, D. Z., Gu, F., Parada, I., Prince, D. A., Becker, A. J., Heinemann, U., Friedman, A., & Kaufer, D. Scientific Reports.

Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.
Bekenstein, U., Mishra, N., Milikovsky, D. Z., Hanin, G., Zelig, D., Sheintuch, L., Berson, A., Greenberg, D. S., Friedman, A., & Soreq, H. Proceedings of the National Academy of Sciences of the United States of America.

Role of neural barriers in the pathogenesis and outcome of Streptococcus pneumoniae meningitis.
Prager, O., Friedman, A., & Nebenzahl, Y. M. Experimental and Therapeutic Medicine.

Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro.
Schoknecht, K., Berndt, N., Rösner, J., Heinemann, U., Dreier, J. P., Kovács, R., Friedman, A., & Liotta, A. International Journal of Molecular Sciences.

Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.
Bekenstein, U., Mishra, N., Milikovsky, D. Z., Hanin, G., Zelig, D., Sheintuch, L., Berson, A., Greenberg, D. S., Friedman, A., & Soreq, H. Proceedings of the National Academy of Sciences.

2016

Automated Cross-Sectional Measurement Method of Intracranial Dural Venous Sinuses.
Lublinsky, S., Friedman, A., Kesler, A., Zur, D., Anconina, R., & Shelef, I. AJNR. American Journal of Neuroradiology.
Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses
Soreq, H., Friedman, A., & Kaufer, D. Wiley-Blackwell.

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